When assessing your patients’ risk for coronary heart disease (CHD), your clinical suspicions may be higher than their clinical risk scores.

Introducing the PLAC® Test for Lp-PLA2 Activity (PLAC® Activity)

The PLAC® Activity Test is an FDA-cleared test that aids in predicting risk for CHD in patients with no prior history of cardiovascular events. The PLAC Activity Test provides physicians with additional prognostic information that was previously unavailable with traditional risk factors.

Assessing patients' risk for CHD events remains a challenge in primary prevention

Event risk prediction with the PLAC Activity Test

Demonstrated across multiple clinical trials and patient populations

The REGARDS± multicenter study and the PLAC Activity Test

±REasons for Geographic and Racial Differences in Stroke.

Figure 3

The PLAC Activity Test is clearly associated with CHD event risk end points

References: 1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497. 2.Sachdeva A, Cannon CP, Deedwania PC, et al. Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines. Am Heart J. 2009;157(1):111-117.e2. 3. US Preventive Services Task Force. Final recommendation statement: lipid disorders in adults (cholesterol, dyslipidemia): screening, June 2008. http://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/lipid-disorders- in-adults-cholesterol-dyslipidemia-screening#. Published December 2014. Accessed April 29, 2015. 4. Thompson A, Gao P, Orfei L, et al; Lp-PLA2 Studies Collaboration. Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet. 2010;375(9725):1536-1544. 5. PLAC® Test for Lp-PLA2 Activity [package insert]. South San Francisco, CA: Diadexus, Inc; 2015. 6. 3rd Annual American Society for Preventive Cardiology Cardiovascular Disease Preventive Conference, 2015. Symposium of REGARDS Lp-PLA2 Substudy.